Details of the Drug

General Information of Drug (ID: DMAHMT9)

Drug Name
Glutathione
Synonyms
glutathione; 70-18-8; Glutathion; Isethion; Tathion; Glutathione-SH; Glutinal; reduced glutathione; Neuthion; Deltathione; Copren; L-Glutathione reduced; Glutide; Tathione; Triptide; Ledac; Glutatione; GSH; Glutatiol; Panaron; gamma-L-Glutamyl-L-cysteinylglycine; Glutathione SH; L-Glutatione; Glutathione (reduced); Agifutol S; L-gamma-glutamyl-L-cysteinylglycine; gamma-L-glutamyl-L-cysteinyl-glycine; 5-L-Glutamyl-L-cysteinylglycine; Glutathione [JAN]; glutathione red; gamma-L-Glutamylcysteinylglycine; red. glutathione
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [1]
Affected Organisms
Humans and other mammals
ATC Code
V03AB32: Glutathione
V03AB: Antidotes
V03A: ALL OTHER THERAPEUTIC PRODUCTS
V03: ALL OTHER THERAPEUTIC PRODUCTS
V: VARIOUS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 307.33
Logarithm of the Partition Coefficient (xlogp) -4.5
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 6
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C10H17N3O6S
IUPAC Name
(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
Canonical SMILES
C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N
InChI
InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
InChIKey
RWSXRVCMGQZWBV-WDSKDSINSA-N
Cross-matching ID
PubChem CID
124886
ChEBI ID
CHEBI:16856
CAS Number
70-18-8
UNII
GAN16C9B8O
DrugBank ID
DB00143
TTD ID
D02HFD
VARIDT ID
DR00039
INTEDE ID
DR2036

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Enzyme unspecific (Enz) TT3C1VN NOUNIPROTAC Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [3]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [4]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [5]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [6]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [7]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Glutathione S-transferase omega-2 (GSTO2) DEHMPZR GSTO2_HUMAN Substrate [9]
Glutathione S-transferase omega-1 (GSTO1) DEZSNJD GSTO1_HUMAN Substrate [9]
Glutathione peroxidase 6 (GPX6) DEOS3FD GPX6_HUMAN Substrate [10]
Gamma-glutamyltranspeptidase 5 (GGT5) DEH6CAO GGT5_HUMAN Substrate [11]
Gamma-glutamylcyclotransferase (GGCT) DEKW6PB A0A073ACX1_RALSL Substrate [12], [13]
Gamma-glutamylcyclotransferase 2 (CHAC2) DEB4JZV CHAC2_HUMAN Substrate [14]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Protein Interaction/Cellular Processes [15]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Post-Translational Modifications [16]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Regulation of Drug Effects [17]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [18]
Arsenite methyltransferase (AS3MT) OTNLWD0N AS3MT_HUMAN Protein Interaction/Cellular Processes [19]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Regulation of Drug Effects [20]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Regulation of Drug Effects [20]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Regulation of Drug Effects [20]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Gene/Protein Processing [21]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [18]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 10.6723 14.1862 7.9021 5.7248
CAL-72 GDSC2 9.4621 14.4961 6.8507 14.9659
MG-63 GDSC2 10.0055 13.5766 7.7339 8.2099
ES6 GDSC2 10.0752 16.7572 6.2119 16.7208
EW-7 GDSC2 10.3013 12.9291 8.2547 4.3827
EW-24 GDSC2 10.4149 14.2315 7.7075 7.4173
HOS GDSC2 10.5261 15.309 7.263 9.7954
CADO-ES1 GDSC2 10.8819 12.5141 8.7629 0.8611
A-673 GDSC2 10.9072 15.3667 7.4967 7.6097
EW-3 GDSC2 11.0309 13.5111 8.4217 2.2523
EW-22 GDSC2 11.0627 14.149 8.1584 3.5814
TC-71 GDSC2 11.0901 12.5794 8.8276 0.4832
CAL-78 GDSC2 11.0983 18.7742 5.982 15.3119
G-292 clone A141B1 GDSC2 11.1155 13.323 8.5446 1.5636
EW-16 GDSC2 11.123 12.9154 8.7128 0.8538
U2OS GDSC2 11.1458 13.6353 8.4286 2.072
H-EMC-SS GDSC2 11.196 19.0093 5.9374 15.3003
SaOS-2 GDSC2 11.2152 16.3172 7.2484 8.396
HuO-3N1 GDSC2 11.224 13.9372 8.3403 2.4052
EW-1 GDSC2 11.2512 16.7105 7.0853 9.2292
SK-ES-1 GDSC2 11.2844 13.0691 8.7235 0.697
CHSA8926 GDSC2 11.3225 13.6822 8.4973 1.5549
NY GDSC2 11.3497 17.2792 6.8799 10.1482
ES8 GDSC2 11.4255 13.3143 8.6897 0.7161
EW-18 GDSC2 11.4524 13.4895 8.6338 0.8907
EW-11 GDSC2 11.4569 14.4468 8.244 2.5813
MHH-ES-1 GDSC2 11.4618 14.7797 8.1025 3.2842
ES1 GDSC2 11.4811 13.9702 8.4555 1.5755
SK-PN-DW GDSC2 11.5612 13.2511 8.7682 0.4088
ES4 GDSC2 11.5885 13.7756 8.5822 0.9754
NOS-1 [Human HNSCC] GDSC2 11.6846 13.7746 8.6237 0.7648
SJSA-1 GDSC2 11.7028 13.2289 8.8293 0.2226
HuO9 GDSC2 11.756 13.7845 8.6495 0.6409
EW-13 GDSC2 11.764 13.5299 8.7458 0.3774
ES7 GDSC2 12.4493 14.6706 8.5985 0.4499
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-26 GDSC2 10.725 12.3044 8.7744 0.9579
KYSE-50 GDSC2 10.9616 14.8354 7.7825 5.8592
SK-GT-4 GDSC2 11.1694 22.4761 4.2139 22.3963
KYAE-1 GDSC2 11.1838 13.7217 8.4115 2.1081
KYSE-220 GDSC2 11.2358 14.6071 8.0525 3.8813
FLO-1 GDSC2 11.3354 14.3777 8.2093 2.9144
ESO-51 GDSC2 11.5039 13.2656 8.7402 0.5126
OACM5.1 C GDSC2 11.6127 13.814 8.5779 0.9729
OACP4 C GDSC2 11.8275 13.8941 8.6378 0.6357
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 11.8717 13.9247 8.6443 0.5929
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-SH GDSC2 9.6475 13.0756 7.7091 9.2822
Kelly GDSC2 10.0196 19.7381 4.6833 23.5881
SK-N-FI GDSC2 10.1192 18.738 5.2607 21.0328
SJNB-14 GDSC2 10.3667 19.0488 5.2994 20.2162
NH-12 GDSC2 10.434 13.0095 8.302 3.8491
NB1 GDSC2 10.4426 37.7197 -3.9542 38.1012
GI-ME-N GDSC2 10.4451 15.1652 7.2752 9.912
SK-N-AS GDSC2 10.4734 12.1374 8.7184 1.5026
GOTO GDSC2 10.4776 12.7407 8.4526 2.9134
SJNB-7 GDSC2 10.5852 16.2076 6.8667 11.918
SK-N-DZ GDSC2 10.6441 12.4471 8.6751 1.4989
NB69 GDSC2 10.6869 15.3875 7.3375 8.9993
SiMa GDSC2 10.8283 13.3946 8.3617 2.8502
TGW GDSC2 10.9217 18.2639 6.104 15.131
SJNB-10 GDSC2 10.9894 13.7077 8.3133 2.8665
SJNB-13 GDSC2 11.1223 13.3381 8.5417 1.5693
NB(TU)1 GDSC2 11.1847 13.0834 8.6743 0.9503
IMR-5 GDSC2 11.2001 12.5863 8.8687 0.3146
CHP-212 GDSC2 11.2157 12.5983 8.8704 0.3039
KP-N-YN GDSC2 11.4519 13.5315 8.6173 0.9512
SK-N-BE(2)-M17 GDSC2 11.4602 13.2402 8.732 0.5607
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 10.8198 14.4683 7.8643 5.658
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Evsa-T GDSC2 9.9394 11.8707 8.5182 3.5491
MDA-MB-453 GDSC2 10.0437 12.9097 8.0882 5.9427
CAMA-1 GDSC2 10.2282 12.3564 8.4771 3.2167
UACC-812 GDSC2 10.2642 12.2165 8.5642 2.6511
OCUB-M GDSC2 10.2823 16.8096 6.3453 15.4881
CAL-120 GDSC2 10.2858 12.0571 8.6496 2.1383
MDA-MB-468 GDSC2 10.2911 14.3626 7.5565 8.6045
BT-474 GDSC2 10.298 12.613 8.4013 3.5268
HCC38 GDSC2 10.2987 17.9343 5.8002 18.1492
MDA-MB-415 GDSC2 10.3592 15.7314 6.9352 12.0792
CAL-148 GDSC2 10.5204 11.9875 8.8058 1.0297
HCC1806 GDSC2 10.5421 12.3157 8.678 1.6145
MDA-MB-175-VII GDSC2 10.578 12.2974 8.7046 1.4373
HCC1187 GDSC2 10.5783 15.5876 7.1644 10.246
MDA-MB-436 GDSC2 10.6904 15.6771 7.2 9.7857
MCF-7 GDSC2 10.6969 13.556 8.2115 3.8933
HCC1937 GDSC2 10.7383 12.6262 8.6475 1.5169
HCC2157 GDSC2 10.7513 12.3043 8.7867 0.8816
HCC1954 GDSC2 10.7562 12.7931 8.5856 1.7952
BT-549 GDSC2 10.7628 23.106 3.5908 25.3539
MFM-223 GDSC2 10.7963 12.5317 8.7157 1.1394
CAL-51 GDSC2 10.8065 15.6465 7.295 8.9831
MDA-MB-157 GDSC2 10.8108 13.6452 8.2389 3.5462
HDQ-P1 GDSC2 10.8157 13.272 8.409 2.6175
MDA-MB-231 GDSC2 10.8255 12.5469 8.7235 1.0762
DU4475 GDSC2 10.8545 12.1822 8.8796 0.462
HCC1419 GDSC2 10.8603 12.3054 8.8351 0.6076
HCC70 GDSC2 10.9064 20.4536 5.0151 20.0408
JIMT-1 GDSC2 10.9678 12.8264 8.6772 1.1338
EFM-192A GDSC2 11.0218 12.6594 8.7682 0.7278
Hs 578T GDSC2 11.0578 13.0047 8.6474 1.1727
HCC1395 GDSC2 11.0754 16.8563 6.897 10.6369
EFM-19 GDSC2 11.2292 14.6352 8.0361 3.9799
CAL-85-1 GDSC2 11.2555 15.2473 7.7736 5.3772
ZR-75-30 GDSC2 11.3811 13.1226 8.7436 0.5709
MDA-MB-361 GDSC2 11.4173 13.2819 8.6985 0.6921
HCC1500 GDSC2 11.4628 13.0211 8.8132 0.3396
T-47D GDSC2 11.5254 16.6153 7.3072 7.4712
AU565 GDSC2 11.5614 15.1216 8.0072 3.633
MRK-nu-1 GDSC2 11.585 12.8868 8.9048 0.129
COLO 824 GDSC2 11.5895 13.8809 8.5414 1.1267
BT-20 GDSC2 11.6029 13.5759 8.6648 0.6839
HCC1143 GDSC2 12.0527 14.5298 8.4916 0.9615
HCC1428 GDSC2 12.5339 28.2059 2.4046 24.8185
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8-MG-BA GDSC2 10.1183 12.333 8.4172 3.7844
NMC-G1 GDSC2 10.2257 15.2858 7.0556 11.7209
KS-1 [Human Krukenberg tumour] GDSC2 10.2934 13.1565 8.1413 5.0747
H4 GDSC2 10.4167 18.7241 5.4991 19.2192
M059J GDSC2 10.4169 12.8589 8.3613 3.5381
CAS-1 GDSC2 10.446 15.3066 7.2068 10.3088
U-251MG GDSC2 10.506 13.478 8.1283 4.7247
D-263MG GDSC2 10.5292 13.0868 8.3252 3.5431
KALS-1 GDSC2 10.596 19.4062 5.2983 19.6348
A-172 GDSC2 10.6244 13.6728 8.1125 4.5916
LN-18 GDSC2 10.7076 17.8077 6.1711 15.3115
DK-MG GDSC2 10.7532 12.0826 8.8748 0.5449
LN-229 GDSC2 10.8317 18.9965 5.6779 17.3741
SK-MG-1 GDSC2 10.8343 13.429 8.3497 2.905
Becker GDSC2 10.9156 17.2704 6.5848 12.6807
GI-1 GDSC2 10.9227 19.1467 5.6714 17.1841
GB-1 GDSC2 10.9578 17.108 6.6936 12.0026
KINGS-1 GDSC2 10.9591 13.1193 8.5517 1.7088
D283 Med GDSC2 10.961 12.3544 8.8589 0.4627
SW1783 GDSC2 10.9621 18.6247 5.9566 15.7535
MOG-G-CCM GDSC2 11.0865 15.0726 7.7504 5.8098
YH-13 GDSC2 11.0969 12.9255 8.6972 0.9353
AM-38 GDSC2 11.1119 12.8848 8.7199 0.8362
LNZTA3WT4 GDSC2 11.1475 18.4191 6.1904 14.1786
42-MG-BA GDSC2 11.235 12.7771 8.8128 0.4468
DBTRG-05MG GDSC2 11.2469 13.6989 8.4531 1.8362
U-118MG GDSC2 11.2546 12.8927 8.7778 0.5399
T98G GDSC2 11.2823 22.9751 4.0523 22.6829
SF268 GDSC2 11.3098 14.1624 8.2887 2.5498
LN-405 GDSC2 11.3137 12.8891 8.803 0.4339
SW1088 GDSC2 11.3421 18.5352 6.2709 13.3406
SF539 GDSC2 11.6164 21.5384 5.0043 18.4394
GaMG GDSC2 11.6921 21.8225 4.92 18.6074
ONS-76 GDSC2 11.7678 15.3181 8.0333 3.2179
MOG-G-UVW GDSC2 11.9272 13.8729 8.6851 0.4569
D-392MG GDSC2 12.0987 24.9941 3.6622 22.1625
Daoy GDSC2 12.3132 21.8334 5.3494 15.5374
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC2 9.832 12.937 7.9199 7.4911
TGBC24TKB GDSC2 10.8615 15.1589 7.5652 7.3076
ETK-1 GDSC2 11.2852 13.2215 8.6649 0.9049
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC2 9.4087 14.309 6.9004 14.836
EN GDSC2 10.3401 15.4104 7.0789 11.304
MFE-319 GDSC2 10.784 14.6758 7.7434 6.429
ESS-1 GDSC2 10.9343 14.9067 7.7317 6.2023
KLE GDSC2 10.9405 13.1328 8.5364 1.8042
MFE-296 GDSC2 11.1956 15.7376 7.5088 6.9712
RL95-2 GDSC2 11.2935 13.9242 8.3819 2.1166
MFE-280 GDSC2 11.637 13.7808 8.6012 0.8725
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 127 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCI-M1 GDSC2 8.0614 9.8316 7.7798 14.1851
SU-DHL-5 GDSC2 8.5733 9.8292 8.3266 8.8828
Jiyoye GDSC2 9.182 10.9791 8.374 6.4216
KE-37 GDSC2 9.5511 11.8473 8.2448 6.1815
A3/Kawakami GDSC2 9.5662 12.286 8.0383 7.4413
HC-1 GDSC2 9.6416 11.2943 8.5878 3.7971
BL-41 GDSC2 9.6649 15.658 6.4349 16.6879
AMO1 GDSC2 9.7821 11.8056 8.4395 4.3826
P32/ISH GDSC2 9.8367 11.5665 8.5943 3.308
MOLT-16 GDSC2 9.8781 11.3214 8.739 2.3523
HL-60 GDSC2 9.9444 12.9575 7.9932 6.7605
SUP-M2 GDSC2 9.9871 11.5298 8.7108 2.3088
ST486 GDSC2 9.9914 12.1608 8.4142 4.0672
IM-9 GDSC2 10.0892 11.741 8.6763 2.3216
Karpas-231 GDSC2 10.1848 11.8259 8.695 2.0523
WSU-DLCL2 GDSC2 10.2208 12.073 8.6038 2.5025
SUP-T1 GDSC2 10.2232 12.5573 8.3796 3.7979
P31/FUJ GDSC2 10.2469 18.0132 5.721 18.6552
SCC-3 GDSC2 10.3203 11.339 8.9744 0.5111
DEL GDSC2 10.3305 11.6173 8.8659 0.9661
Karpas-620 GDSC2 10.3403 12.2966 8.5732 2.4713
NOMO-1 GDSC2 10.348 12.1204 8.657 1.9998
NALM-6 GDSC2 10.3504 13.1879 8.1642 4.8214
LAMA-84 GDSC2 10.3578 19.2947 5.1703 20.7816
RPMI-8402 GDSC2 10.3964 16.0738 6.7942 12.7791
KY821 GDSC2 10.4056 11.9601 8.759 1.3893
Namalwa GDSC2 10.4339 16.64 6.5432 14.0568
MOLM-13 GDSC2 10.4734 12.5021 8.558 2.3402
OCI-AML-5 GDSC2 10.5079 11.5377 8.9788 0.3603
CTV-1 GDSC2 10.5094 12.3716 8.636 1.873
Ramos.2G6.4C10 GDSC2 10.5354 12.6843 8.512 2.4926
Karpas-1106P GDSC2 10.5573 12.2513 8.7136 1.4196
SU-DHL-10 GDSC2 10.5623 11.4743 9.0239 0.2047
K-562 GDSC2 10.5758 13.1994 8.3018 3.594
L-428 GDSC2 10.5837 12.2462 8.7292 1.3126
EJM GDSC2 10.5881 12.9456 8.4249 2.8842
BC-1 GDSC2 10.5909 28.6646 0.6867 32.3326
U-698-M GDSC2 10.5991 18.4428 5.7772 17.4884
JSC-1 GDSC2 10.6101 12.5356 8.6191 1.8201
RPMI-6666 GDSC2 10.6151 12.3241 8.7123 1.3555
L-1236 GDSC2 10.6302 19.6579 5.1996 19.9647
U266B1 GDSC2 10.6422 12.6863 8.5709 2.0224
ME1 GDSC2 10.6522 11.9217 8.8932 0.5527
EM-2 GDSC2 10.6683 12.9392 8.4738 2.4936
KMS-12-BM GDSC2 10.7031 12.8674 8.5249 2.1744
VAL GDSC2 10.7228 12.6027 8.6494 1.5261
EoL-1 GDSC2 10.7265 13.197 8.3919 2.8442
Reh GDSC2 10.7955 12.2156 8.8417 0.6317
MOLP-8 GDSC2 10.8065 12.3258 8.8034 0.7668
SU-DHL-6 GDSC2 10.8069 12.5464 8.7147 1.1328
Granta-519 GDSC2 10.828 12.5202 8.7355 1.0227
ALL-SIL GDSC2 10.8811 12.4503 8.7877 0.7653
WIL2 NS GDSC2 10.9053 12.5407 8.7629 0.841
ATN-1 GDSC2 10.9157 12.0411 8.9556 0.2239
Karpas-422 GDSC2 10.9375 12.4639 8.8073 0.65
GA-10 GDSC2 10.9518 12.2908 8.8789 0.4077
RPMI-8866 GDSC2 10.9549 12.602 8.761 0.807
MN-60 GDSC2 10.9646 12.9346 8.6314 1.3359
EB2 GDSC2 10.9789 12.5577 8.789 0.6849
Daudi GDSC2 10.9795 12.7696 8.7056 1.0046
H9 GDSC2 10.9796 13.279 8.4944 1.9596
Raji GDSC2 10.9881 12.1722 8.9363 0.2403
SK-MM-2 GDSC2 10.9909 12.6916 8.7418 0.8509
KOPN-8 GDSC2 10.9947 12.7411 8.724 0.9174
HDLM-2 GDSC2 11.0015 13.7759 8.2899 2.9718
DB GDSC2 11.0132 19.8245 5.4048 18.1547
VL51 GDSC2 11.0399 13.7089 8.3407 2.6515
CA46 GDSC2 11.042 13.1064 8.5982 1.4019
YT GDSC2 11.0599 12.4009 8.8815 0.3452
OCI-AML-2 GDSC2 11.067 12.0655 9.0021 0.097
DG-75 GDSC2 11.0903 13.188 8.5881 1.3961
TUR GDSC2 11.0997 12.6365 8.8101 0.5318
Hs 445 GDSC2 11.1005 12.4507 8.8792 0.3322
MEG-01 GDSC2 11.1088 13.2034 8.5907 1.3655
CML-T1 GDSC2 11.1138 12.6028 8.8285 0.4669
OPM-2 GDSC2 11.1143 12.5552 8.8464 0.4145
KM-H2 GDSC2 11.121 13.0244 8.6688 1.0266
DND-41 GDSC2 11.1266 12.9223 8.7117 0.8551
Ku812 GDSC2 11.1328 19.048 5.8731 15.751
ALL-PO GDSC2 11.1336 13.3533 8.5409 1.5605
L-363 GDSC2 11.1368 19.2701 5.7673 16.2368
ML-2 GDSC2 11.1439 12.6757 8.8136 0.4948
WSU-NHL GDSC2 11.1478 12.6687 8.8178 0.4797
BV-173 GDSC2 11.1819 13.014 8.7003 0.8542
JJN-3 GDSC2 11.1921 12.6287 8.8503 0.3651
JURL-MK1 GDSC2 11.2002 12.6721 8.8376 0.3954
KCL-22 GDSC2 11.2181 12.8178 8.7909 0.5212
MM1.S GDSC2 11.2221 12.5962 8.8736 0.2937
CESS GDSC2 11.2309 13.0222 8.7186 0.7512
Karpas-45 GDSC2 11.262 13.2687 8.6359 1.0347
BE-13 GDSC2 11.2779 30.1864 0.4716 31.313
MV4-11 GDSC2 11.2824 13.0775 8.7194 0.7122
TK [Human B-cell lymphoma] GDSC2 11.2956 12.9772 8.763 0.5615
L-540 GDSC2 11.3055 13.1442 8.7037 0.7501
ARH-77 GDSC2 11.3269 12.8545 8.8209 0.3796
PF-382 GDSC2 11.3584 13.0308 8.7686 0.5088
Jurkat GDSC2 11.3665 12.7665 8.8675 0.2532
MLMA GDSC2 11.3744 18.8952 6.1191 14.0207
GDM-1 GDSC2 11.3794 13.4697 8.6093 1.0392
BALL-1 GDSC2 11.3798 13.1038 8.7501 0.5519
RPMI-8226 GDSC2 11.3806 12.8013 8.8605 0.2634
NCI-H929 GDSC2 11.3818 12.957 8.805 0.3954
CCRF-CEM GDSC2 11.3902 13.0176 8.7862 0.442
A4/Fukuda GDSC2 11.3927 12.8202 8.8583 0.2637
697 GDSC2 11.3973 12.9952 8.7972 0.4089
MOLT-4 GDSC2 11.4235 12.8202 8.8697 0.2297
LC4-1 GDSC2 11.4348 13.0842 8.7794 0.4384
Karpas-299 GDSC2 11.4537 13.0088 8.8141 0.3411
JVM-2 GDSC2 11.463 13.6478 8.5766 1.096
NKM-1 GDSC2 11.4642 13.7786 8.5251 1.2997
JVM-3 GDSC2 11.4659 13.3978 8.6749 0.7386
SR GDSC2 11.4885 13.2612 8.7356 0.5341
SU-DHL-8 GDSC2 11.4964 12.8957 8.8701 0.2068
MHH-PREB-1 GDSC2 11.5087 13.0032 8.8369 0.2687
HH [Human lymphoma] GDSC2 11.5255 14.1682 8.3956 1.7917
HAL-01 GDSC2 11.5819 13.1503 8.8123 0.2958
P30/OHK GDSC2 11.6023 12.8987 8.9068 0.1229
MOLT-13 GDSC2 11.6184 13.1249 8.8348 0.2373
SUP-B15 GDSC2 11.6853 13.1129 8.8631 0.1694
KMOE-2 GDSC2 11.6868 13.4891 8.7307 0.4482
CTB-1 GDSC2 11.7005 24.2799 3.7208 22.8246
KG-1 GDSC2 11.7732 13.4791 8.7674 0.3246
GR-ST GDSC2 11.8324 14.2388 8.5088 1.0579
RS4;11 GDSC2 11.8414 13.4888 8.7893 0.2568
SUP-HD1 GDSC2 11.9694 13.5934 8.7994 0.2036
Mono-Mac-6 GDSC2 12.0861 15.0803 8.2906 1.6887
Loucy GDSC2 12.1577 24.8313 3.7849 21.6516
⏷ Show the Full List of 127 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB GDSC2 9.102 11.6543 7.9677 9.2332
KMRC-20 GDSC2 9.5488 15.931 6.2045 18.2281
SW13 GDSC2 9.906 17.12 5.8983 18.7373
A-704 GDSC2 10.0522 12.2615 8.4071 3.9812
A-498 GDSC2 10.2469 12.1389 8.5893 2.5391
KMRC-1 GDSC2 10.5681 12.6346 8.5526 2.2248
SN12C GDSC2 10.7395 12.8261 8.5625 1.9322
OS-RC-2 GDSC2 10.8829 13.2356 8.4619 2.248
BFTC-909 GDSC2 11.0281 13.8289 8.2813 2.9778
LB996-RCC GDSC2 11.036 13.5956 8.3878 2.4158
CAL-54 GDSC2 11.1758 18.5377 6.1528 14.3008
ACHN GDSC2 11.3596 13.4647 8.6024 1.0827
KTCTL-195 GDSC2 11.4076 13.1035 8.7614 0.5028
769-P GDSC2 11.5673 21.8282 4.827 19.2479
TK-10 GDSC2 11.6293 14.4497 8.33 1.974
786-O GDSC2 11.8157 21.6449 5.0948 17.6368
VMRC-RCZ GDSC2 12.1102 21.754 5.2483 16.3788
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LS513 GDSC2 10.0332 11.6909 8.6647 2.4906
COLO 320HSR GDSC2 10.096 12.2538 8.44 3.6933
C2BBe1 GDSC2 10.2094 12.3384 8.4736 3.2726
RCM-1 [Human ESC] GDSC2 10.2348 14.8863 7.259 10.5109
SW1417 GDSC2 10.3381 15.01 7.2739 10.1731
HT-55 GDSC2 10.3477 20.4881 4.569 23.1465
SW48 GDSC2 10.363 17.1431 6.2415 15.816
SW1463 GDSC2 10.3954 12.3606 8.5765 2.3628
LS180 GDSC2 10.4056 12.0624 8.7146 1.6129
HT-29 GDSC2 10.4269 15.2932 7.1996 10.3959
SW837 GDSC2 10.4765 12.9305 8.3649 3.4102
MDST8 GDSC2 10.4964 15.4952 7.1509 10.5144
CCK-81 GDSC2 10.5363 13.6952 8.0456 5.1512
RKO GDSC2 10.6295 14.4563 7.7457 6.7304
LS1034 GDSC2 10.6992 16.2607 6.9226 11.3382
SNU-C1 GDSC2 10.7377 12.1984 8.8227 0.7495
SW1116 GDSC2 10.7586 19.2345 5.5061 18.3273
LS411N GDSC2 10.76 11.8946 8.9483 0.3104
SNU-407 GDSC2 10.7882 13.3053 8.3787 2.8201
HCT 116 GDSC2 10.8367 18.4795 5.9361 16.1514
COLO205 GDSC2 10.8494 17.1848 6.5793 12.8628
GP5d GDSC2 10.8739 13.4907 8.3447 2.8717
KM12 GDSC2 10.9319 12.7275 8.7004 1.0706
T84 GDSC2 10.9358 14.2718 8.0276 4.5136
SNU-175 GDSC2 10.9528 12.9691 8.6114 1.4389
SW948 GDSC2 10.9772 12.5101 8.8066 0.6241
HCC2998 GDSC2 10.997 13.4386 8.435 2.2305
SK-CO-1 GDSC2 11.0486 12.6323 8.7902 0.6307
DiFi GDSC2 11.1542 14.1439 8.2124 3.1547
LoVo GDSC2 11.1787 13.4763 8.5121 1.6419
SW626 GDSC2 11.2603 19.9365 5.5306 17.0242
CW-2 GDSC2 11.2975 16.1292 7.3902 7.4421
CaR-1 GDSC2 11.3305 13.3396 8.6387 0.9672
HCT 15 GDSC2 11.382 12.7304 8.886 0.2109
SNU-C2B GDSC2 11.4454 14.5334 8.2007 2.8099
SNU-61 GDSC2 11.4567 13.2022 8.7447 0.5251
SW620 GDSC2 11.4646 17.8898 6.6652 11.0533
SNU-C5 GDSC2 11.4676 13.5818 8.6046 0.9862
NCI-H747 GDSC2 11.5983 13.824 8.5676 1.0213
COLO 678 GDSC2 11.7443 13.6126 8.7083 0.4803
CL-11 GDSC2 11.7798 19.8217 5.9524 13.9456
LS123 GDSC2 11.8375 23.8929 4.0117 21.5875
NCI-H716 GDSC2 11.8862 13.5877 8.7712 0.2783
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 11.032 12.4903 8.8371 0.4881
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-HEP-1 GDSC2 9.9333 17.1751 5.8925 18.6901
JHH-6 GDSC2 9.9487 11.8654 8.527 3.4762
SNU-387 GDSC2 10.5511 20.7614 4.5915 22.5475
HuH-1 GDSC2 10.6312 14.5727 7.6912 7.0479
Huh-7 GDSC2 10.7418 12.8474 8.5546 1.9692
SNU-423 GDSC2 10.908 15.2862 7.5354 7.3849
JHH-4 GDSC2 11.1337 13.7174 8.3872 2.2898
HLE GDSC2 11.1493 13.5731 8.4568 1.9327
SNU-398 GDSC2 11.2313 15.2313 7.7662 5.4604
Hep-G2/C3A GDSC2 11.275 23.363 3.8552 23.3432
JHH-1 GDSC2 11.3407 12.7076 8.8787 0.2386
JHH-2 GDSC2 11.3562 18.9812 6.0646 14.3265
JHH-7 GDSC2 11.5778 24.194 3.672 23.2448
SNU-449 GDSC2 13.5507 25.3223 4.5121 16.4576
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 127 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1092 GDSC2 9.015 10.132 8.6394 5.3054
NCI-H847 GDSC2 9.397 11.0416 8.5239 4.8388
SBC-5 GDSC2 9.8564 12.244 8.2788 5.2027
NCI-H1651 GDSC2 9.9062 12.3562 8.2598 5.2035
NCI-H526 GDSC2 10.1968 12.4858 8.3961 3.7524
NCI-H2122 GDSC2 10.2082 13.2083 8.0586 5.7549
NCI-H1876 GDSC2 10.2794 12.3319 8.5202 2.8744
NCI-H82 GDSC2 10.3097 14.2338 7.6326 8.1039
NCI-H64 GDSC2 10.3178 13.482 8.0019 5.8601
NCI-H727 GDSC2 10.3446 14.2681 7.6406 7.9764
NCI-H1975 GDSC2 10.3529 12.7092 8.391 3.4842
NCI-H1781 GDSC2 10.3594 12.8244 8.3413 3.7605
NCI-H2461 GDSC2 10.4076 16.3673 6.658 13.5021
COR-L279 GDSC2 10.4363 12.7481 8.4245 3.1427
COLO 668 GDSC2 10.44 13.0665 8.2792 3.9702
NCI-H524 GDSC2 10.5497 13.5577 8.1189 4.6955
NCI-H1435 GDSC2 10.5651 20.8361 4.5652 22.6087
SW1271 GDSC2 10.5857 18.1788 5.8975 16.953
NCI-H226 GDSC2 10.5889 12.2476 8.7313 1.2966
NCI-H810 GDSC2 10.6203 13.6911 8.1013 4.6637
NCI-H1688 GDSC2 10.649 13.2446 8.3251 3.3369
Lu-139 GDSC2 10.6662 14.697 7.6553 7.1856
NCI-H196 GDSC2 10.6979 12.722 8.5854 1.8724
NCI-H720 GDSC2 10.7238 11.7461 8.9881 0.2241
NCI-H358 GDSC2 10.7376 14.6391 7.7304 6.5984
HCC827 GDSC2 10.7445 13.007 8.4864 2.3153
NCI-H1694 GDSC2 10.7464 12.1598 8.8419 0.6689
LC-1/sq GDSC2 10.7522 14.6717 7.7245 6.6033
COR-L23 GDSC2 10.7543 12.1433 8.8518 0.6261
IA-LM GDSC2 10.7696 19.3086 5.4778 18.4251
SBC-3 GDSC2 10.7714 21.4513 4.4188 22.6269
NCI-H2347 GDSC2 10.7747 14.5589 7.7926 6.1611
NCI-H69 GDSC2 10.7955 14.7317 7.7245 6.5163
DMS 114 GDSC2 10.8165 13.3173 8.3894 2.7201
NCI-H2066 GDSC2 10.817 12.7083 8.6527 1.4009
NCI-H2141 GDSC2 10.8222 12.5006 8.7407 1.0064
PaCa-3 GDSC2 10.8303 14.0189 8.0797 4.4048
NCI-H2085 GDSC2 10.8372 17.719 6.3095 14.2993
EBC-1 GDSC2 10.8386 16.2526 7.0247 10.4491
NCI-H520 GDSC2 10.8388 12.9895 8.5447 1.8909
NCI-H1573 GDSC2 10.8394 12.6258 8.6978 1.1732
NCI-H3122 GDSC2 10.8529 16.5737 6.8792 11.2279
VMRC-LCD GDSC2 10.8676 12.4228 8.7925 0.758
Ms-1 GDSC2 10.8872 12.6168 8.7242 1.0135
Calu-3 GDSC2 10.8902 17.9372 6.2411 14.5212
SK-MES-1 GDSC2 10.8937 13.2989 8.4402 2.344
NCI-H650 GDSC2 10.8963 12.736 8.68 1.193
NCI-H2023 GDSC2 10.9137 15.5027 7.4362 7.9443
NCI-H1755 GDSC2 10.9166 13.3302 8.4389 2.3191
NCI-H522 GDSC2 10.9402 17.0517 6.7085 11.962
NCI-H1563 GDSC2 10.9403 14.6753 7.8437 5.549
NCI-H2009 GDSC2 10.9669 16.3538 7.0645 9.9439
NCI-H1648 GDSC2 10.9704 13.1389 8.5491 1.7078
NCI-H1944 GDSC2 10.9858 12.985 8.621 1.3599
NCI-H2369 GDSC2 10.991 12.5451 8.7991 0.6404
EKVX GDSC2 10.9968 14.8675 7.7896 5.7526
UMC-11 GDSC2 11.0013 14.7592 7.8428 5.4415
NCI-H1693 GDSC2 11.0056 14.6724 7.8857 5.1904
NCI-H441 GDSC2 11.0248 24.2582 3.2212 25.815
PC-14 GDSC2 11.0249 13.3639 8.4816 1.9648
NCI-H596 GDSC2 11.0295 12.9859 8.6416 1.2249
NCI-H446 GDSC2 11.0377 12.7968 8.7214 0.891
NCI-H1048 GDSC2 11.047 18.8961 5.8853 15.8934
LCLC-97TM1 GDSC2 11.0522 13.6891 8.3559 2.5561
CPC-N GDSC2 11.0524 13.5486 8.4169 2.2482
HARA [Human squamous cell lung carcinoma] GDSC2 11.0608 12.748 8.7508 0.7614
COR-L95 GDSC2 11.0691 13.3103 8.5269 1.697
NCI-H1915 GDSC2 11.0702 12.6213 8.8036 0.5716
NCI-H1568 GDSC2 11.0773 13.5448 8.4317 2.143
NCI-H661 GDSC2 11.0882 12.9909 8.6671 1.0626
NCI-H835 GDSC2 11.092 20.3267 5.216 18.7727
NCI-H1341 GDSC2 11.118 12.4624 8.8818 0.3177
LK-2 GDSC2 11.1204 13.4545 8.4921 1.8
COR-L88 GDSC2 11.1292 13.056 8.66 1.0546
NCI-H23 GDSC2 11.1315 14.2478 8.1535 3.5008
NCI-H1993 GDSC2 11.1495 17.7101 6.536 12.4091
DMS 53 GDSC2 11.1499 12.7787 8.7773 0.6065
LOU-NH91 GDSC2 11.15 13.508 8.4845 1.8012
RERF-LC-KJ GDSC2 11.1707 12.8929 8.7424 0.7106
HOP-62 GDSC2 11.1819 14.3689 8.1282 3.5591
NCI-H2170 GDSC2 11.1832 14.8907 7.8933 4.8375
NCI-H2591 GDSC2 11.1924 14.1338 8.238 2.9664
NCI-H1793 GDSC2 11.2003 12.8076 8.7874 0.5425
NCI-H2795 GDSC2 11.2294 20.8241 5.0727 19.0416
EPLC-272H GDSC2 11.2318 13.4398 8.553 1.4048
LXF 289 GDSC2 11.2512 24.8499 3.1014 25.6384
NCI-H1155 GDSC2 11.2753 12.5658 8.9044 0.2081
Lu-65 GDSC2 11.2924 12.8552 8.807 0.4336
NCI-H1703 GDSC2 11.2969 13.1145 8.7114 0.7296
NCI-H2373 GDSC2 11.301 12.7353 8.8539 0.3085
HCC78 GDSC2 11.3575 13.1098 8.7387 0.6003
HOP-92 GDSC2 11.359 14.5688 8.1386 3.2434
NCI-H1650 GDSC2 11.368 13.5203 8.5841 1.1476
NCI-H2818 GDSC2 11.378 13.9678 8.4062 1.9046
Calu-6 GDSC2 11.4071 13.0709 8.7733 0.4692
COR-L311 GDSC2 11.412 13.4524 8.6306 0.9332
DMS 273 GDSC2 11.4215 12.9516 8.8224 0.3346
NCI-H2228 GDSC2 11.437 15.2187 7.8939 4.4178
NCI-H1623 GDSC2 11.4565 18.9076 6.1703 13.5894
SW1573 GDSC2 11.4613 13.8524 8.494 1.431
NCI-H513 GDSC2 11.4671 13.1682 8.7614 0.4717
NCI-H2087 GDSC2 11.4957 14.3218 8.3169 2.1847
NCI-H1581 GDSC2 11.4965 12.8748 8.8774 0.1935
NCI-H2722 GDSC2 11.5305 18.3043 6.5113 11.7154
NCI-H2405 GDSC2 11.5507 15.3167 7.915 4.1301
NCI-H209 GDSC2 11.5538 13.8765 8.5271 1.2122
NCI-H1792 GDSC2 11.561 13.831 8.5483 1.1237
NCI-H2595 GDSC2 11.5671 13.468 8.6906 0.6249
NCI-H1299 GDSC2 11.5681 13.5939 8.6434 0.7761
NCI-H1355 GDSC2 11.5889 17.1727 7.0867 8.5529
KNS-62 GDSC2 11.5917 19.9212 5.774 15.1804
HCC15 GDSC2 11.6309 14.1173 8.4663 1.3873
NCI-H2342 GDSC2 11.6498 18.393 6.549 11.2747
NCI-H1963 GDSC2 11.6666 13.6365 8.6683 0.6353
Lu-135 GDSC2 11.6921 13.3616 8.7787 0.3297
NCI-H2731 GDSC2 11.7 15.9891 7.6996 5.0402
A-549 GDSC2 11.7203 13.4045 8.774 0.3295
EMC-BAC-2 GDSC2 11.756 13.8441 8.6272 0.7093
COR-L105 GDSC2 11.7819 14.5445 8.3646 1.6675
NCI-H1666 GDSC2 11.8339 19.4886 6.149 12.8932
Lu-165 GDSC2 11.8371 23.174 4.3637 20.3767
NCI-H1838 GDSC2 11.8594 13.4057 8.8246 0.1893
Lu-99A GDSC2 11.8602 13.9161 8.6428 0.6033
SHP-77 GDSC2 11.8898 23.5748 4.2057 20.8171
NCI-H322M GDSC2 11.9498 14.0107 8.6437 0.5547
LCLC-103H GDSC2 12.0108 22.9447 4.6006 19.1427
RERF-LC-Sq1 GDSC2 12.1651 14.1205 8.687 0.3586
⏷ Show the Full List of 127 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 10.6175 12.3737 8.6926 1.4471
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-9 GDSC2 9.8246 11.9346 8.4071 4.4837
KYSE-150 GDSC2 10.0402 11.4929 8.7606 1.929
KYSE-270 GDSC2 10.5683 14.1185 7.8659 6.1468
KYSE-450 GDSC2 10.5741 17.9511 6.0013 16.481
TE-4 GDSC2 10.5866 12.8307 8.4757 2.6089
OE19 GDSC2 10.5966 13.0912 8.3639 3.2087
TE-5 GDSC2 10.651 13.6862 8.1229 4.482
KYSE-520 GDSC2 10.7429 13.2363 8.3838 2.8626
TE-6 GDSC2 10.8182 15.0038 7.6103 7.1342
TE-15 GDSC2 10.8876 13.816 8.2067 3.5979
TE-8 GDSC2 10.9024 20.6836 4.8985 20.514
OE21 GDSC2 10.9821 12.993 8.6159 1.3867
OE33 GDSC2 10.9823 13.6915 8.3165 2.8596
TE-1 GDSC2 11.0024 14.2159 8.093 4.0356
KYSE-180 GDSC2 11.1254 14.861 7.8721 5.055
T.T GDSC2 11.1723 13.207 8.6193 1.1816
COLO 680N GDSC2 11.2861 12.6738 8.8702 0.2766
EC-GI-10 GDSC2 11.2992 21.9453 4.5727 20.8186
TE-10 GDSC2 11.3228 19.8047 5.64 16.3913
KYSE-70 GDSC2 11.4504 17.0937 7.0345 9.106
KYSE-140 GDSC2 11.8023 16.5536 7.5044 5.9159
KYSE-410 GDSC2 11.8819 13.6843 8.7354 0.3554
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EFO-21 GDSC2 9.977 12.7799 8.1038 6.0006
OV56 GDSC2 10.0358 17.2644 5.9288 18.2348
TYK-nu GDSC2 10.0452 11.8503 8.5977 2.8598
ES-2 GDSC2 10.139 12.6116 8.2981 4.4554
RMG-I GDSC2 10.3966 13.7856 7.9098 6.245
Caov-4 GDSC2 10.4806 12.8592 8.4003 3.2024
Caov-3 GDSC2 10.5346 12.4261 8.626 1.8893
SK-OV-3 GDSC2 10.5752 15.6004 7.1559 10.3018
OVCAR-3 GDSC2 10.6821 13.4592 8.2469 3.7191
OVKATE GDSC2 10.9268 18.6755 5.9059 16.0796
TOV-21G GDSC2 10.9327 12.33 8.8564 0.4877
OVTOKO GDSC2 10.9487 13.7626 8.266 3.1787
OC 314 GDSC2 11.1094 24.6706 3.0816 26.0097
A2780 GDSC2 11.111 14.4499 8.0509 4.0889
OV-90 GDSC2 11.2018 13.4005 8.5546 1.428
OVISE GDSC2 11.2412 18.2453 6.3408 13.2115
DOV13 GDSC2 11.2554 13.9324 8.3588 2.2745
OAW28 GDSC2 11.309 21.9989 4.5536 20.8667
OVCAR-4 GDSC2 11.3739 19.1626 5.989 14.6515
Kuramochi GDSC2 11.4129 16.0338 7.5072 6.5757
OVCAR-5 GDSC2 11.4223 17.0935 7.0163 9.2614
OVCAR-8 GDSC2 11.4621 12.9141 8.851 0.2551
IGROV-1 GDSC2 11.5852 13.6935 8.6125 0.8698
TOV-112D GDSC2 11.6371 13.7138 8.6268 0.7855
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MIA PaCa-2 GDSC2 9.9997 11.5159 8.7252 2.2028
KP-4 GDSC2 10.1098 12.2935 8.4303 3.7234
HuP-T3 GDSC2 10.2072 12.298 8.4911 3.1748
Capan-1 GDSC2 10.3066 13.9323 7.7769 7.242
Panc 10.05 GDSC2 10.5212 14.3701 7.7139 7.1477
SU.86.86 GDSC2 10.5991 12.7661 8.5118 2.3956
DAN-G GDSC2 10.641 14.2958 7.8297 6.2116
PaTu 8988t GDSC2 10.6493 11.7522 8.9565 0.3457
HPAC GDSC2 10.7909 13.0171 8.5072 2.1429
Hs 766T GDSC2 10.885 18.0478 6.1832 14.8245
KP-2 GDSC2 11.0203 12.0418 8.9937 0.1193
CFPAC-1 GDSC2 11.0247 15.471 7.5243 7.2149
SW1990 GDSC2 11.0848 17.5438 6.5714 12.3678
Capan-2 GDSC2 11.1407 19.3383 5.7367 16.3689
PL4 GDSC2 11.1935 13.0067 8.7083 0.8158
Panc 04.03 GDSC2 11.2295 17.3365 6.7713 10.9863
SUIT-2 GDSC2 11.2528 12.5208 8.9119 0.2004
BxPC-3 GDSC2 11.2529 15.0363 7.8686 4.8557
AsPC-1 GDSC2 11.3092 13.9205 8.3915 2.0525
Panc 08.13 GDSC2 11.3432 13.0988 8.7369 0.6146
KP-3 GDSC2 11.388 18.6054 6.2689 13.2503
KP-1N GDSC2 11.462 13.2378 8.7336 0.5547
Panc 02.03 GDSC2 11.4754 13.5446 8.6225 0.9143
PaTu 8902 GDSC2 11.4754 12.8502 8.8783 0.1979
Panc 03.27 GDSC2 11.4988 17.3688 6.936 9.5428
YAPC GDSC2 11.5852 21.9851 4.7631 19.4546
PSN1 GDSC2 12.3545 20.0997 6.2022 11.6046
HuP-T4 GDSC2 12.4401 25.1585 3.8279 20.9352
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 10.0464 15.3789 6.874 13.2204
NCI-H2452 GDSC2 10.3343 22.3746 3.6189 26.3125
MPP 89 GDSC2 10.5291 12.4388 8.6174 1.9415
NCI-H28 GDSC2 10.8548 19.052 5.6678 17.3643
IST-Mes1 GDSC2 10.9846 16.5455 6.9843 10.3526
NCI-H2052 GDSC2 11.4123 13.3987 8.6516 0.8568
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 10.242 21.6118 3.9259 25.6034
DU145 GDSC2 10.8002 17.0605 6.6047 12.842
22Rv1 GDSC2 10.8653 13.549 8.3139 3.0497
VCaP GDSC2 11.0042 20.3446 5.1421 19.2882
PC-3 GDSC2 11.3234 14.0099 8.3609 2.1807
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 10.731 12.8201 8.5606 1.9533
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHL-1 GDSC2 8.0273 10.2384 7.5847 15.4531
RPMI-7951 GDSC2 9.7184 12.2096 8.1937 6.0689
IGR-1 GDSC2 10.0538 11.9014 8.5792 2.9516
UACC-62 GDSC2 10.1261 13.5897 7.8155 7.4218
WT2-iPS GDSC2 10.2093 12.3286 8.4781 3.2464
A2058 GDSC2 10.2903 15.2663 7.1131 11.2281
WM115 GDSC2 10.3708 13.2247 8.1601 4.8043
IGR-37 GDSC2 10.4279 12.9312 8.3346 3.6717
Mel JuSo GDSC2 10.4689 17.7731 6.01 16.7032
UACC-257 GDSC2 10.4875 14.3519 7.6996 7.3055
COLO 792 GDSC2 10.5019 12.6132 8.5246 2.4767
A-375 GDSC2 10.7227 13.1963 8.3901 2.8602
SK-MEL-1 GDSC2 10.7352 11.9497 8.9178 0.4142
RVH-421 GDSC2 10.7829 18.2858 5.9916 16.0135
IST-MEL1 GDSC2 10.7881 16.787 6.7295 12.1974
HMV-II GDSC2 10.8017 14.1078 8.021 4.7903
GAK GDSC2 10.8526 12.1873 8.8769 0.4719
G-361 GDSC2 10.9253 15.7877 7.3079 8.6556
WM35 GDSC2 10.9594 17.815 6.3506 13.8019
MeWo GDSC2 11.0288 12.9232 8.6667 1.1193
COLO 829 GDSC2 11.0878 13.4998 8.4564 2.0094
WM1552C GDSC2 11.0881 18.4614 6.1274 14.6269
COLO 679 GDSC2 11.1029 13.1456 8.6115 1.2814
WM278 GDSC2 11.1841 15.1953 7.7539 5.6128
LOX-IMVI GDSC2 11.1888 12.996 8.7104 0.8116
SH-4 GDSC2 11.3031 13.1308 8.7078 0.7377
HT-144 GDSC2 11.3538 17.3765 6.8362 10.3753
WM793 GDSC2 11.3755 13.3086 8.6705 0.8166
SK-MEL-24 GDSC2 11.6801 20.6903 5.4629 16.3804
A101D GDSC2 13.079 22.9365 5.3333 14.1258
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VA-ES-BJ GDSC2 9.8519 11.9929 8.3982 4.4756
SW684 GDSC2 10.0391 15.6416 6.7381 14.0049
SW982 GDSC2 10.1133 15.2424 6.9926 12.3689
Rh18 GDSC2 10.3896 13.876 7.8616 6.5492
MFH-ino GDSC2 10.4098 13.4899 8.0599 5.3205
EW-8 GDSC2 10.4575 12.4537 8.5705 2.2972
SK-LMS-1 GDSC2 10.6038 13.6349 8.1172 4.6031
Rh30 GDSC2 10.6893 13.5929 8.1899 4.0294
Hs 633.T GDSC2 10.9259 16.5844 6.925 10.8107
SK-UT-1 GDSC2 10.9545 14.689 7.8463 5.508
A-204 GDSC2 11.0238 13.2447 8.5316 1.7276
MES-SA GDSC2 11.1053 12.1781 8.9772 0.1254
SW872 GDSC2 11.1901 13.342 8.5729 1.3603
RD GDSC2 11.2145 17.2116 6.8211 10.7501
GCT GDSC2 11.257 13.0102 8.7344 0.6786
HT-1080 GDSC2 11.3272 13.0482 8.7493 0.5852
KYM-1 GDSC2 11.4182 18.5722 6.3058 12.9997
Rh41 GDSC2 11.5598 13.2128 8.7815 0.376
G-401 GDSC2 11.857 14.0447 8.5935 0.754
RKN GDSC2 13.7782 25.876 4.399 16.459
G-402 GDSC2 13.9704 23.9256 5.4345 12.1565
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN45 GDSC2 9.8651 16.3559 6.2467 17.1141
AGS GDSC2 9.9528 13.5116 7.7268 8.3836
Hs 746.T GDSC2 10.3901 15.0744 7.2801 10.0131
NCI-N87 GDSC2 10.4715 14.0434 7.8369 6.5208
NUGC-3 GDSC2 10.5725 13.6932 8.0699 4.9381
HSC-39 GDSC2 10.5878 13.1846 8.3158 3.4937
Fu97 GDSC2 10.635 13.7522 8.0821 4.7478
SNU-5 GDSC2 10.6461 12.3043 8.7362 1.2083
RF-48 GDSC2 10.7052 14.1969 7.9183 5.5657
23132/87 GDSC2 10.7988 12.3929 8.7731 0.8937
ECC10 GDSC2 10.9306 14.8949 7.7349 6.1912
NUGC-4 GDSC2 10.9629 15.7698 7.3417 8.3836
OCUM-1 GDSC2 11.1127 14.0494 8.2311 3.1177
GCIY GDSC2 11.1213 12.8742 8.7282 0.798
SK-GT-2 GDSC2 11.1552 14.7325 7.9488 4.5774
IM95 GDSC2 11.1614 19.5282 5.6588 16.6773
KATO III GDSC2 11.2343 13.4599 8.5459 1.4327
SNU-1 GDSC2 11.2416 13.0246 8.7222 0.7307
SNU-16 GDSC2 11.2955 12.4865 8.9391 0.1409
RERF-GC-1B GDSC2 11.5238 14.2933 8.3429 2.0316
HGC-27 GDSC2 11.7171 13.348 8.7929 0.2899
TGBC11TKB GDSC2 11.7924 25.9577 2.9624 24.8506
MKN28 GDSC2 12.2967 21.7846 5.3616 15.5188
SNG-M GDSC2 10.4622 16.1473 6.8066 12.5486
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC2 9.8653 12.9883 7.9196 7.4101
CAL-62 GDSC2 10.1282 18.4561 5.4082 20.377
ASH-3 GDSC2 10.1684 12.6612 8.2942 4.4176
TT GDSC2 10.4278 17.0986 6.3124 15.2869
CGTH-W-1 GDSC2 10.709 16.5002 6.8128 11.9248
K5 GDSC2 10.7455 16.8555 6.6656 12.6434
BHT-101 GDSC2 10.7848 14.9384 7.6194 7.1498
B-CPAP GDSC2 10.9594 12.3556 8.8578 0.4671
FTC-133 GDSC2 11.0148 13.1433 8.5695 1.5611
8305C GDSC2 11.1384 21.0204 4.9089 19.9103
8505C GDSC2 11.4051 13.6717 8.5406 1.2903
HTC-C3 GDSC2 11.5278 13.765 8.5595 1.1083
WRO GDSC2 11.7635 23.1442 4.3249 20.674
TT2609-C02 GDSC2 11.9666 13.7589 8.7407 0.3138
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 GDSC2 9.94 11.3705 8.7555 2.1374
CAL-27 GDSC2 9.9984 14.0906 7.4752 9.8053
PCI-30 GDSC2 10.0316 12.9957 8.0376 6.281
HO-1-N-1 GDSC2 10.1097 13.5655 7.8154 7.4607
UPCI-SCC-090 GDSC2 10.1099 13.0268 8.078 5.8544
Detroit 562 GDSC2 10.1728 14.0165 7.6405 8.3765
CAL-33 GDSC2 10.4464 18.0038 5.8788 17.3948
HSC-3 GDSC2 10.5239 12.1058 8.7581 1.2467
Ca9-22 GDSC2 10.5584 19.5767 5.185 20.2065
SCC-15 GDSC2 10.5984 16.1433 6.9077 11.6573
JHU-022 GDSC2 10.7265 14.4804 7.7983 6.2237
HSC-4 GDSC2 10.7567 12.1465 8.8516 0.6251
HO-1-u-1 GDSC2 10.7953 18.7634 5.7657 17.0572
SCC-4 GDSC2 10.8541 12.4837 8.7623 0.8879
SAS GDSC2 10.88 19.6048 5.4142 18.434
SKN-3 GDSC2 10.9828 14.0962 8.1357 3.8327
BICR 78 GDSC2 10.9922 14.2817 8.0571 4.252
BICR 22 GDSC2 11.0634 19.7087 5.4987 17.6245
LB771-HNC GDSC2 11.2315 15.0682 7.8412 5.0434
FaDu GDSC2 11.2589 13.7403 8.4418 1.8748
SCC-9 GDSC2 11.3683 15.1682 7.8768 4.62
SAT [Human HNSCC] GDSC2 11.6853 14.5453 8.3179 1.9685
DOK GDSC2 11.7307 23.9475 3.9066 22.1645
OSC-20 GDSC2 11.7533 14.218 8.4819 1.2199
NCI-H3118 GDSC2 11.8688 21.4482 5.2279 16.9736
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC2 9.6079 13.886 7.2736 12.0605
SW1710 GDSC2 10.1022 21.7663 3.7374 26.544
RT-4 GDSC2 10.1599 12.3933 8.4158 3.7087
CAL-29 GDSC2 10.3653 12.7559 8.377 3.542
SW780 GDSC2 10.4311 14.0887 7.7876 6.9025
HT-1197 GDSC2 10.4595 14.1215 7.7912 6.8195
639V GDSC2 10.5303 19.2587 5.3211 19.7037
647V GDSC2 10.5865 15.3953 7.2637 9.6532
HT-1376 GDSC2 10.6062 15.2303 7.3575 9.0624
TCCSUP GDSC2 10.6563 12.7085 8.5688 2.0134
KU-19-19 GDSC2 10.7054 12.0808 8.8546 0.6539
UM-UC-3 GDSC2 10.9307 12.4083 8.8257 0.5903
5637 GDSC2 11.3637 18.1219 6.4854 12.2031
J82 GDSC2 11.7326 13.3662 8.7922 0.2859
RT-112 GDSC2 12.5634 24.4653 4.252 19.2605
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC2 8.6938 9.7399 8.4899 7.4346
C-33 A GDSC2 10.0316 13.6603 7.712 8.2807
ME-180 GDSC2 10.2167 13.2824 8.0287 5.9174
CAL-39 GDSC2 10.2873 12.6086 8.3965 3.5748
DoTc2 4510 GDSC2 10.3947 12.777 8.3855 3.4393
SKG-IIIa GDSC2 10.5513 14.335 7.7511 6.8622
NCC-IT GDSC2 10.6712 14.8217 7.599 7.5059
OVCA420 GDSC2 10.7228 15.2423 7.4322 8.3705
NT2-D1 GDSC2 10.7899 17.9973 6.1385 15.2749
PWR-1E GDSC2 10.8602 19.4277 5.4867 18.1643
C-4-I GDSC2 10.8885 14.1273 8.0653 4.3836
SiHa GDSC2 10.8937 12.3915 8.8163 0.65
OVMIU GDSC2 10.8975 16.7728 6.8139 11.4862
PEO1 GDSC2 10.9814 13.1278 8.5593 1.6466
SiSo GDSC2 10.982 13.2379 8.5131 1.8656
KGN GDSC2 10.9859 24.336 3.1525 26.0948
MS751 GDSC2 11.0385 12.7864 8.7259 0.873
SKN GDSC2 11.054 13.9421 8.2457 3.1272
HEC-1 GDSC2 11.058 12.399 8.8814 0.3462
LB831-BLC GDSC2 11.0823 14.0834 8.1989 3.3336
NEC8 GDSC2 11.4006 12.6466 8.9216 0.1438
SW756 GDSC2 11.4436 12.8815 8.8556 0.2518
DSH1 GDSC2 11.5158 13.4129 8.6901 0.6571
Ca Ski GDSC2 11.5571 14.2091 8.3941 1.7653
BPH-1 GDSC2 11.8264 14.0025 8.5967 0.7626
HEY GDSC2 11.9688 13.8962 8.6927 0.4205
HT-3 GDSC2 12.0337 13.9918 8.6832 0.4167
HeLa GDSC2 12.0447 23.1376 4.5308 19.3289
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6737).
2 Methionine and cysteine affect glutathione level, glutathione-related enzyme activities and the expression of glutathione S-transferase isozymes in rat hepatocytes. J Nutr. 1997 Nov;127(11):2135-41.
3 Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology. 2007 Nov;46(5):1597-610.
4 Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503.
5 Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos. 2008 Dec;36(12):2571-81.
6 Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2. J Biol Chem. 2010 May 28;285(22):16582-7.
7 Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855.
8 Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells. BMC Pharmacol Toxicol. 2015 Dec 15;16:37.
9 Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases. J Mol Biol. 2012 Jul 13;420(3):190-203.
10 Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism. PLoS One. 2014 Jan 2;9(1):e84583.
11 Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15;414(2):208-14.
12 Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. Biochem Biophys Res Commun. 2020 Mar 12;523(3):759-765.
13 Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study. BJOG. 2019 Feb;126(3):349-358.
14 ChaC2, an enzyme for slow turnover of cytosolic glutathione. J Biol Chem. 2017 Jan 13;292(2):638-651.
15 A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis. J Neurochem. 2004 Jun;89(5):1241-51. doi: 10.1111/j.1471-4159.2004.02428.x.
16 Posttranslational glutathiolation of aldose reductase (AKR1B1): a possible mechanism of protein recovery from S-nitrosylation. Chem Biol Interact. 2009 Mar 16;178(1-3):250-8. doi: 10.1016/j.cbi.2008.11.007. Epub 2008 Nov 18.
17 Protective effect of Geraniol on the transgenic Drosophila model of Parkinson's disease. Environ Toxicol Pharmacol. 2016 Apr;43:225-31. doi: 10.1016/j.etap.2016.03.018. Epub 2016 Mar 22.
18 Apoptosis induced by extracellular glutathione is mediated by H(2)O(2) production and DNA damage. Int J Cancer. 2000 Aug 1;87(3):343-8. doi: 10.1002/1097-0215(20000801)87:3<343::aid-ijc6>3.0.co;2-8.
19 Rapid equilibrium kinetic analysis of arsenite methylation catalyzed by recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT). J Biol Chem. 2012 Nov 9;287(46):38790-9. doi: 10.1074/jbc.M112.368050. Epub 2012 Sep 6.
20 Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium. Carcinogenesis. 2010 Aug;31(8):1450-5. doi: 10.1093/carcin/bgq125. Epub 2010 Jun 27.
21 Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol. 2012 Apr;168(1):113-24. doi: 10.1111/j.1365-2249.2011.04549.x.